Recent Advances in Epsilon-Poly-L-Lysine and L-Lysine-Based Dendrimer Synthesis, Modification, and Biomedical Applications
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چکیده
منابع مشابه
Cationic poly-L-lysine dendrimer complexes doxorubicin and delays tumor growth in vitro and in vivo.
We report in this study the complexation of the chemotherapeutic drug doxorubicin (DOX) with the novel sixth-generation cationic poly-l-lysine dendrimer (DM) (MW 8149 kDa), which we previously reported to exhibit systemic antiangiogenic activity in tumor-bearing mice. DOX-DM complexation was confirmed by florescence polarization measurement, proton nuclear magnetic resonance spectroscopy, and m...
متن کاملSynthesis and Phase Behavior of Poly(N-isopropylacrylamide)-b-Poly(L-Lysine Hydrochloride) and Poly(N-Isopropylacrylamide-co-Acrylamide)-b-Poly(L-Lysine Hydrochloride)
The synthesis of poly(N-isopropylacrylamide)-b-poly(L-lysine) and poly(N- isopropylacrylamide-co-acrylamide)-b-poly(L-lysine) copolymers was accomplished by combining atom transfer radical polymerization (ATRP) and ring opening polymerization (ROP). For this purpose, a di-functional initiator with protected amino group was successfully synthetized. The ATRP of N-isopropylacrylamide yielded narr...
متن کاملAntimicrobial, antioxidant, and antitumor activity of epsilon-poly-L-lysine and citral, alone or in combination
BACKGROUND Food safety is an important worldwide public health concern, and microbial contamination in foods not only leads to food deterioration and shelf life reduction but also results in economic losses and disease. OBJECTIVE The main aim of the present study was to evaluate the effect of epsilon-poly-L-lysine (ε-PL) and citral combination against Escherichia coli O157:H7 (E. coli O157:H7...
متن کاملGenome Sequence of Streptomyces albulus PD-1, a Productive Strain for Epsilon-Poly-l-Lysine and Poly-l-Diaminopropionic Acid
Streptomyces albulus PD-1, a productive strain for epsilon-poly-l-lysine and poly-l-diaminopropionic acid, was isolated from soils. We present the genome sequence of S. albulus PD-1, which may provide abundant information regarding the production of epsilon-poly-l-lysine and poly-l-diaminopropionic acid.
متن کاملInteraction of Poly-l-lysine with Chromatin
The priming capacity of chromatin of fixed nuclei and chromosomes for exogenous DNA polymerase can be evaluated radioautographically by the incorporation of labeled nucleotides. It had previously been reported that acid fixation or acid treatment of alcohol-fixed tissues led to increased priming when calf thymus DNA polymerases, specific for single-stranded DNA, were used. We employed Escherich...
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ژورنال
عنوان ژورنال: Frontiers in Chemistry
سال: 2021
ISSN: 2296-2646
DOI: 10.3389/fchem.2021.659304